“EFFECT OF TEMPERATURE ON REFRACTROMETRIC STUDY OF TRIZINOTHIOCARBAMIDES IN 70% DIOXANE-WATER MIXTURE”
Keywords:1-(4-hydroxy-6-methyl)-S-triazino-3-phenylthiocarbamides, Dioxane-Water mixture, Refractrometry study
The pharmaceutical and medicinal applications of the synthesized drugs, it is a prior duty of chemist to investigate pharmacokinetic and pharmacodynamics of that drug for studying drug absorption, transmission metabolism and drug execration, hence it become essential to investigate the solute-solvent, solvent-solvent and solute-solute-solvent interactions of that drug. (Here solute means drug) These interactions were directly hamper the potency of that drug as well as the drug activity and effect. This study explores the potency of newly synthesized drugs, stability of drug and also to renovate and modify the traditional drugs which are used by medicinal practioners. S-triazine and thiocarbamide group containing drug create their own identity in pharmaceutical and medicinal sciences. Refractrometric measurements of recently synthesized drugs viz. 1-(4-hydroxy-6-methyl)-S-triazino-3-methylthiocarbamide (L1) is carried out at 70% percentage composition of solvent and at different temperatures to investigate effects of structure, groups on S-triazino thiocarbamides. The data and the results obtained during this investigation gave detail information regarding drug absorption, transmissions activity and effect of these drugs. Taking all these things in to consideration this research work was carried out.