Main Article Content

Abstract

MicroRNAs (miRNAs) play important roles in carcinogenesis. Up to date, miR-124 deregulation has been linked to the malignancy of breast cancer (BC), nasopharyngeal cancer (NPC), bladder cancer (BCa), colorectal cancer (CRC), non-small cell lung cancer (NSCLC), gliobastoma (GB) and hepatocellular carcinoma (HCC). Potentially acting as a tumor growth suppressor, miR-124 was commonly down-regulated in clinical surgical specimens from patients suffering with above cancers. MiR-124 deficiency enhanced the development and progressions of BC, NPC, BCa, NSCLC, CRC, GB and HCC and contributes in the advance of patient’s TNM stage. MiR-124 expression level was reversely correlated with lymph node metastasis of NSCLC patients and survival time of BC patients. MiR-124 was generally down-regulated in above cancer cell lines. Consequently, restored miR-124 over-expression led to the increased in vitro apoptosis, decreased in vitro proliferation, migration and invasion capacities and the decreased in vivo tumorigenesis and malignancy of corresponding cancer cell lines. MiR-124 functions in carcinogenesis through the interactions with diverse genes and proteins. STAT3 was most commonly regulated by miR-124 dysexpression in above cancers, followed by sp1, CD151, CDK4 and NF-kB. LncRNAs including MALAT1, NEATI and HOXA11-ASwere involved in miR-124-mediated tumorigenesis for NPC and NSCLC. MiR-124 plays an important role in tumor cell malignancy and cancer development and progression. Its use in the understanding of carcinogenesis, diagnosis and treatment of cancers is worthy of further study.

Keywords

Carcinogenesis, miR-124, breast cancer, nasopharyngeal cancer, bladder cancer, colorectal cancer

Article Details

How to Cite
[1]
Abdul Wakil Qarluq, Edrees Khan Rahmatzada, Bashir Ahmad, Shuqing Liu, and Ming-Zhong Sun, “MIR-124 DEFICIENCY POTENTIALLY PROMOTES THE PROGRESSIONS OF CERTAIN CANCERS”, IEJRD - International Multidisciplinary Journal, vol. 6, no. 5, p. 15, Sep. 2021.

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