INFLUENCE OF "TINIDAZOL" IN NATURAL HERBS ON THE HUMAN BODY

Abstract

Tinidazole has a high absorption rate, bioavailability is about 100%. Plasma protein binding - 12-12.5%. After a dose of 2 g, Cmax is reached after 2 hours and is 41-52 μg / ml, after 24 hours - 10-19 μg / ml, after 72 hours - 0.9-1 μg / ml. Vd - 50 l. Penetrates through the BBB and the placental barrier. It is excreted in breast milk within 72 hours after ingestion. It is metabolized in the liver to form pharmacologically active hydroxylated derivatives, which inhibit the growth of anaerobic microorganisms and may enhance the effect of tinidazole. T1 / 2 is excreted by the kidneys after 12-14 hours with 52% bile, 24% (unchanged) and 11-12% (as metabolites) due to reabsorption in the renal tubules. Tinidazole can cause trichomoniasis (a sexually transmitted disease in women and men), giardiasis (an intestinal infection that causes diarrhea, gas, and stomach cramps), and amoebiasis (which can lead to diarrhea. Intestinal infection) is used to treat gas that can spread to other organs such as stomach and liver cramps). Tinidazole is also used to treat bacterial vaginosis in women (an infection caused by an overgrowth of harmful bacteria in the vagina). The class of drugs called antimicrobials also includes tinidazole and nitroimidazole. It works by killing the organisms that cause the infection, but antibiotics are not used for colds, flu, or other viral infections. Overuse of antibiotics increases the risk of an infection that is then not treatable with antibiotics.