ROLE OF NATURAL NUTRACEUTICAL INGREDIENTS IN HOLISTIC RECOVERY OF AFFECTED HUMAN ORGANS DUE TO COVID 19 INFECTION AND ITS TREATMENT

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Rajashri K. Mundhe
Dr Vijaya Deshmukh

Abstract

Nutraceutical industry has emerged as a research-oriented sector and its demand during the Covid 19 pandemic has increased tremendously. There is a rapid change in the consumer health consciousness and their lifestyle post covid which have led to a swift growth in a Natural nutraceutical Market. Nutraceuticals are now looked upon as important supplements that are on the priority list of monthly expenses, which, like food, cannot be skipped and has wide range of nutritional as well as therapeutic benefits.


Antiviral drugs such as remdesivir, ritonavir, and lopinavir are also being used; however, they are known to cause severe side effects on different organs [56].


After first phase of Covid-19, the second wave affects a lot to the Indians with mysterious fungal infection known as Mucor mycosis.


The purpose of this study was to understand post covid 19 effects during the treatment and post treatment on specific organs such as brain, lungs, heart, bones, liver, kidneys, skin etc. and effectiveness of natural nutraceutical ingredients to nourish that specific organ and boost overall immunity including side effects of medications provided during the treatment and long-term side effects.


This is a review paper of COVID-19’s extensive effects on virtually all the organs and how do natural nutraceutical ingredients will help in recovering fast.

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How to Cite
[1]
Rajashri K. Mundhe and Dr Vijaya Deshmukh, “ROLE OF NATURAL NUTRACEUTICAL INGREDIENTS IN HOLISTIC RECOVERY OF AFFECTED HUMAN ORGANS DUE TO COVID 19 INFECTION AND ITS TREATMENT”, IEJRD - International Multidisciplinary Journal, vol. 7, no. MGM IOM&R, p. 13, Jun. 2022.

References

  1. Agrawal, U., Raju, R., &Udwadia, Z. F. (2020). Favipiravir: A new and emerging antiviral option in COVID-19. Medical journal, Armed Forces India, 76(4), 370–376. https://doi.org/10.1016/j.mjafi.2020.08.004
  2. Ahmadi, R.; Salari, S.; Sharifi, M.D.; Reihani, H.; Rostamiani, M.B.; Behmadi, M.; Taherzadeh, Z.; Eslami, S.; Rezayat, S.M.; Jaafari, M.R.; et al. Oral nano-curcumin formulation efficacy in the management of mild to moderate outpatient COVID-19: A randomized triple-blind placebo-controlled clinical trial. Food Sci. Nutr. 2021, 9, 4068–4075.
  3. Alam, N., Hossain, M., Khalil, M. I., Moniruzzaman, M., AmrahSulaiman, Siti., and Gan, S. H. (2011). High catechin concentrations detected in Withaniasomnifera (Ashwagandha) by high performance liquid chromatography analysis. BMC Complement. Altern. Med. 11 (August), 65. doi:10.1186/1472- 6882-11-65
  4. Anwer, T., Sharma, M., Pillai, K. K., and Khan, G. (2012). Protective effect of Withaniasomnifera against oxidative stress and pancreatic beta-cell damage in type 2 diabetic rats. Acta Pol. Pharm. 69 (6), 1095–1101.
  5. Arora, S., Hemmige, V. S., Mandke, C., Chansoria, M., Rawat, S., Dravid, A....Puius, Y. A. (2021). Online Registry of COVID-19–Associated Mucormycosis Cases, India, 2021. Emerging Infectious Diseases, 27(11), 2963-2965. https://doi.org/10.3201/eid2711.211322.
  6. Benjamin Bowe, Yan Xie et al. (November 2021), Kidney Outcomes in Long COVID JASN November 2021, 32 (11) 2851-2862; DOI: https://doi.org/10.1681/ASN.2021060734
  7. Bessière F, Roccia H, Delinière A, et al. JAMA Cardiol, 2020 Assessment of QT intervals in a case series of patients with coronavirus disease 2019 (COVID-19) infection treated with hydroxychloroquine alone or in combination with azithromycin in an intensive care unit.
  8. C. John Sperati, M.D., M.H.S. , (May 14, 2020), Coronavirus: Kidney Damage Caused by COVID-19, John Hopkins medicine- Health https://www.hopkinsmedicine.org/health/conditions-and diseases/coronavirus/coronavirus-kidney-damage-caused-by-covid19
  9. Chen, T. et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 368, m1091 (2020)
  10. Chen, T. et al. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ 368, m1091 (2020)
  11. Colavita F, Lapa D, Carletti F, et al.: SARS-CoV-2 isolation from ocular secretions of a patient with COVID-19 in Italy with prolonged viral RNA detection. Ann Intern Med. 2020, M20- 1176. 10.7326/M20-1176
  12. Dehelean C. A., Lazureanu V., Coricovac D., Mioc M., Oancea R., Marcovici I., Pinzaru I., Soica C., Tsatsakis A. M., Cretu O., J. Clin. Med. 2020, 9, 7
  13. Devkar, S. T., Kandhare, A. D., Zanwar, A. A., Jagtap, S. D., Katyare, S. S., Bodhankar, S. L., et al. (2016). Hepatoprotective effect of withanolide-rich fraction in acetaminophen-intoxicated rat: decisive role of TNF-α, IL-1β, COX-II and iNOS. Pharm. Biol. 54 (11), 2394–2403. doi:10.3109/13880209.2016.1157193
  14. Fatemeh Babaei et. al. (2020), Curcumin (a constituent of turmeric): New treatment option against COVID‐19, Food Sci Nutr. 2020 Oct; 8(10): 5215–5227.
  15. Galanakis CM, Rizou M, Aldawoud TMS, Ucak I, Rowan NJ. Innovations and technology disruptions in the food sector within the COVID-19 pandemic and post-lockdown era. Trends Food Sci Technol. 2021; 110:193–200.
  16. Galanakis, C.M. The Food Systems in the Era of the Coronavirus (COVID-19) Pandemic Crisis. Foods 2020, 9, 523.
  17. Gupta, M., and Kaur, G. (2019). Withaniasomnifera (L.) dunal ameliorates neurodegeneration and cognitive impairments associated with systemic inflammation. BMC Complement. Altern. Med. 19 (1), 217. doi:10.1186/s12906-019-2635-0
  18. Han C, Duan C, Zhang S, et al.: Digestive symptoms in COVID-19 patients with mild disease severity: clinical presentation, stool viral RNA testing, and outcomes. Am J Gastroenterol. 2020, 115:916-923.
  19. Helms J, Kremer S, Merdji H, et al.: Neurologic features in severe SARS-CoV-2 infection. N Engl J Med. 2020, 382:2268-2270. 10.1056/NEJMc2008597
  20. Hewlings, S.; Kalman, D. Curcumin: A review of its effects on human health. Foods 2017, 6, 92.
  21. Hirsch J, Ng J, Ross D: Acute kidney injury in patients hospitalized with COVID-19. Kidney Int. 2020, 98:209-218. 10.1016/j.kint.2020.05.006
  22. How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes. (2020). Accessed: 28 June, 2020: https://www.sciencemag.org/news/2020/04/howdoes- coronavirus-kill-clinicians-trace-ferocious-rampage-through-body-bra....
  23. https://covid19-druginteractions.org/checker
  24. https://indianexpress.com/article/explained/mucormycosis-in-covid-patients-fungal-infections-7308721/
  25. https://www.fda.gov/drugs/drug-safety-and-availability/fda-cautions-against-use-hydroxychloroquine-or-chloroquine-covid-19-outside-hospital-setting-or
  26. https://www.hindustantimes.com/india-news/does-ashwagandha-help-in-recovery-from-covid-study-in-3-uk-cities-101627832177597.html
  27. https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/heart-problems-after-covid19
  28. https://www.pathnsitu.com/newsdescription.php?title=diagnostic-aid-for-black-fungus
  29. https://www.who.int/news-room/questions-and-answers/item/coronavirus-disease-(covid-19)-post-covid-19-condition
  30. https://www.who.int/srilanka/news/detail/16-10-2021-post-covid-19-condition
  31. Jain U (August 03, 2020) Effect of COVID-19 on the Organs. Cureus 12(8): e9540. DOI 10.7759/cureus.9540
  32. Janet Sultana et. al. (21 July 2020), Azithromycin in COVID 19 Patients: Pharmacological Mechanism, Clinical Evidence and Prescribing Guidelines, Springer Nature Switzerland AG 2020
  33. Kalra, R., & Kaushik, N. (2017). Withaniasomnifera (Linn.) Dunal: a review of chemical and pharmacological diversity. Phytochemistry Reviews, 16(5), 953-987.
  34. Khalil M. I., Ahmmed I., et al. (2015). Amelioration of isoproterenol-induced oxidative damage in rat myocardium by Withaniasomnifera leaf extract. Biomed. Res. Int. 2015, 624159. 10.1155/2015/624159
  35. Lahiri D, Ardila A: COVID-19 pandemic: a neurological perspective. Cureus. 2020, 12:e7889. 10.7759/cureus.7889
  36. Masataka Nishiga, Dao Wen Wang et al., (2020), COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives, September 2020 | volume 17, NAture Reviews | CARDIOLOGY, page no 543 -558
  37. Mina T. Kelleni (16 March 2021), Resveratrol-zinc nanoparticles or pterostilbene-zinc: Potential COVID-19 mono and adjuvant therapy, Biomedicine & Pharmacotherapy journal
  38. Parasa S, Desai M, Chandrasekar V, et al.: Prevalence of gastrointestinal symptoms and fecal viral shedding in patients with coronavirus disease 2019. A systematic review and metaanalysis. JAMA. 2020, 3:e2011335. 10.1001/jamanetworkopen.2020.11335
  39. Pawar, K.S.; Mastud, R.N.; Pawar, S.K.; Pawar, S.S.; Bhoite, R.R.; Bhoite, R.R.; Kulkarni, M.V.; Deshpande, A.R. Oral curcumin with piperine as adjuvant therapy for the treatment of COVID-19: A randomized clinical trial. Front. Pharmacol. 2021, 12, 669362.
  40. Pawar, P., Gilda, S., Sharma, S., Jagtap, S. H., Paradkar, A., Mahadik, K., et al. (2011). Rectal gel application of Withaniasomnifera root extract expounds anti-inflammatory and muco-restorative activity in TNBS-induced inflammatory bowel disease. BMC Complement. Altern. Med. 11 (April). doi:10.1186/1472-6882-11-34
  41. Pfefferbaum B, North C: Mental health and the Covid-19 pandemic. N Engl J Med. 2020, 10.1056/NEJMp2008017
  42. Puelles V, Lütgehetmann M, Lindenmeyer M, et al.: Multiorgan and renal tropism of SARSCoV- 2. N Engl J Med. 2020, 10.1056/NEJMc2011400
  43. Pushpakom, S. et al. Drug repurposing: progress, challenges and recommendations. Nat. Rev. Drug Discov. 18, 41–58 (2019).
  44. Ramdani LH, Bachari K. (2020), Potential therapeutic effects of Resveratrol against SARS-CoV-2. Acta Virol. 2020;64(3):276-280. doi: 10.4149/av_2020_309. PMID: 32985211.
  45. Saggam A, Limgaokar K, Borse S, Chavan-Gautam P, Dixit S, Tillu G and Patwardhan B (2021) Withaniasomnifera (L.) Dunal: Opportunity for Clinical Repurposing in COVID19 Management. Front. Pharmacol. 12:623795. doi: 10.3389/fphar.2021.623795
  46. Sanders, J. M., Monogue, M. L., Jodlowski, T. Z. &Cutrell, J. B. Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA https://doi.org/10.1001/jama.2020.6019 (2020).
  47. Solomon I, Normandin E, Bhattacharyya S, et al.: Neuropathological features of Covid-19. N Engl J Med. 2020, 10.1056/NEJMc2019373
  48. Tancheva, M. C. Petralia, S. Miteva, S. Dragomanova, A. Solak,R.Kalfin, M. Lazarova, D. Yarkov, R. Ciurleo, E. Cavalli,A. Bramanti, F. Nicoletti,Brain Sci.2020,10(11), 852
  49. Tiruveedi, V. L., Bale, S., Khurana, A., Godugu, C., and Godugu, C. (2018). Withaferin A, a novel compound of Indian ginseng (Withaniasomnifera ), ameliorates Cerulein-induced acute pancreatitis: possible role of oxidative stress and inflammation. Phytotherapy Res. 32 (12), 2586–2596. doi:10.1002/ptr.6200
  50. Vaduganathan M, Vardeny O, Michel T, et al.: Renin-angiotensin-aldosterone system,Inhibitors in patients with Covid-19. N Engl J Med. 2020, 382:1653-1659. 10.1056/NEJMsr2005760
  51. Vahedian-Azimi, A.; Abbasifard, M.; Rahimi-Bashar, F.; Guest, P.C.; Majeed, M.; Mohammadi, A.; Banach, M.; Jamialahmadi, T.; Sahebkar, A. Effectiveness of Curcumin on Outcomes of Hospitalized COVID-19 Patients: A Systematic Review of Clinical Trials. Nutrients 2022, 14, 256. https:/ /doi.org/10.3390/nu14020256
  52. Valentina O. Puntmann, MD, PhD1; et al., July 27, 2020, Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19).
  53. Vareed, S. K., Bauer, A. K., Nair, K. M., Liu, Y., Jayaprakasam, B., Nair, M. G., et al. (2014). Blood-brain barrier permeability of bioactive withanamides present in Withaniasomnifera fruit extract. Phytother. Res. 28 (8), 1260–1264. doi:10.1002/ptr.5118
  54. Vasavan, S. S., Jagadesan, V., Sivanesan, S., and Rajagopalan, V. (2020). Protective effect of Withaniasomnifera on nandrolone decanoate-induced biochemical alterations and hepatorenal toxicity in wistar rats. Pharmacognosy Mag. 16 (68), 218. doi:10.4103/pm.pm_349_19
  55. Vedi, M., and Sabina, E. P. (2016). Assessment of hepatoprotective and nephroprotective potential of withaferin A on bromobenzene-induced injury in Swiss albino mice: possible involvement of mitochondrial dysfunction and inflammation. Cell BiolToxicol 32 (5), 373–390. doi:10.1007/s10565-016-9340-2
  56. Wang M, Cao R, Zhang L, Yang X, Liu J, Xu M, et al. (2020), Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res. (2020) 30:269–71
  57. Wankhede, S., Langade, D., Joshi, K., Sinha, S. R., and Bhattacharyya, S. (2015). Examining the effect of Withaniasomnifera supplementation on muscle strength and recovery: a randomized controlled trial. J. Int. Soc. Sports Nutr. 12, 43. doi:10.1186/s12970-015-0104-9
  58. Whittaker et al. (15 May 2020),Neurological Manifestations of COVID-19: A systematic review and current update
  59. Wu P, Duan F, Luo C, et al.: Characteristics of ocular findings of patients with coronavirus disease 2019 (COVID-19) in Hubei province, China. JAMA Ophthalmol. 2020, 138:575-578.
  60. Yang, C. J., Wei, Y. J., et. al. (2021). Remdesivir use in the coronavirus disease 2019 pandemic: A mini-review. Journal of microbiology, immunology, and infection = Wei mianyugan ran za zhi, 54(1), 27–36.
  61. Zhou L, Xu Z, Castiglione G, et al.: ACE2 and TMPRSS2 are expressed on the human ocular surface, suggesting susceptibility to SARS-CoV-2 infection. BioRxiv. 2020,
  62. Zhou, F. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 395, 1054–1062 (2020).
  63. Ziegenfuss, T. N., Anurag, W. K., Jennifer, E. S., Betsy, J., Kerksick, C., Lopez, H. L., et al. (2018). Effects of an aqueous extract of Withaniasomnifera on strength training adaptations and recovery: the STAR trial. Nutrients 10 (11), 1807. doi:10.3390/nu10111807

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